Annie Lennox abandoned classical studies at London’s Royal Academy of Music to pursue a career as a singer-songwriter. Thirty-six years later, she has sold more than 80 million albums, logged numerous hit singles, and won four Grammys, first as half of the pop duo Eurythmics, then as a critically acclaimed solo artist. A longtime human rights activist, she was recently appointed a goodwill ambassador for UNAIDS. She plans to release a new album later this year.

A version of this article appeared in the October 2010 issue of Harvard Business Review.