The works concern Arthur Dent, an Englishman who wakes up one morning and finds bulldozers about to tear down his house. Around the same time, Earth is about to be destroyed by aliens to make way for an interstellar bypass.
Dent is saved in the nick of time by his friend Ford Prefect, an alien who's been masquerading as an actor.
From there, the series is off and running through the galaxies, where Dent is as clueless and overwhelmed as "Futurama's" Fry in the 31st century. (Indeed, Matt Groening's TV series "Futurama" -- which also features a somewhat traditional sci-fi lineup of human male, attractive but caustic female and an easily agitated robot -- shares a sense of humor with Adams' work, which is no surprise, given Groening's love of Pythonesque humor.)