Jon D. Levenson, Albert A. List Professor of Jewish Studies at Harvard University, gives the inaugural lecture of the Hudi Gross Memorial Lecture Series, co-sponsored by the Duke Center for Jewish Studies. Levenson's lecture, "Genesis 22: The Binding of Isaac and the Crucifixion of Jesus," concentrates on the interpretation of the Hebrew Bible, including its reinterpretations in the "rewritten Bible" of Second Temple Judaism and rabbinic midrash. The episode that Jewish tradition calls "The Binding of Isaac" and Christian tradition terms "The Sacrifice of Isaac" plays a major structuring role in each tradition. In the case of Christianity, the little narrative in Genesis 22 powerfully shaped the way Jesus and his death are presented in the New Testament. In order to understand the full extent of this influence, one has to become aware of the interpretation of the narrative in Second Temple Judaism and how in Jewish tradition it came to be associated with Passover and the theology and institutions connected with that festival. By examining the ways the two traditions have appropriated their common scriptural story, we can understand the relationship between them better and appreciate in an equitable way both the similarities and the differences between them. This lecture, in honor of Hudi Gross, also is in honor of Sam Levine.